Polyclonal Antibody to Dab1 (Ab-232)

DESCRIPTION

The aminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper ayer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full ength nature has not been determined.

DETAILS

Gene: DAB1
App Id: IHC
Antigen: Dab1 (Ab-232)
Gene Id: 1600
Isotype: Rabbit IgG
Format Id: Purified
Uniprot Id: O75553
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human,Mouse,Rat
Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Alternative Name: Disabled homolog 1
Application Note: Predicted MW: 80kd, Immunohistochemistry: 1:50~1:100
Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1.