mouse monoclonal IgA; claudin-11 Antibody (D-8) is an IgA κ mouse monoclonal claudin-11 antibody (also designated CLDN11 antibody) that detects the claudin-11 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. claudin-11 Antibody (D-8) is available as the non-conjugated anti-claudin-11 antibody. The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-8 is a multi-pass membrane protein that belongs to the claudin family. Localized to the caput and the lateral margins of principal cells, claudin-8 plays an important role in tight junction-specific obliteration of the intercellular space.