Defensin α4 rabbit pAb

DETAILS

Isotype: IgG
Category: Antibody
Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Clonality: Polyclonal
Immunogen: The antiserum was produced against synthesized peptide derived from human Defensin alpha4. AA range:27-76
Background: defensin alpha 4(DEFA4) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014],
Reactivity: Human;Rat;Mouse;
Applications: IHC;IF;ELISA
Concentration: 1 mg/ml
Human Gene Id: 1669
Alternative Names: DEFA4; DEF4; Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4
Storage Stability: -20°C/1 year
Human Swiss Prot No: P12838
Subcellular Location: Secreted . Cytoplasmic vesicle, secretory vesicle . Stored as mature peptide in neutrophil granules. .