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CD3-HA2H3-25tests CD3-HA2H3-200tests

APC-Labeled Human Siglec-3 / CD33 Protein, His TagStar Staining

ACROBiosystems

DESCRIPTION

APC-Labeled Human Siglec-3 Protein, His Tag (CD3-HA2H3) is produced via conjugation of APC to Human Siglec-3 Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human Siglec-3 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1).

DETAILS

  • Tag: C-10×His
  • Host: HEK293
  • Size: 25tests
  • Buffer: PBS, 0.2% BSA, pH7.4
  • Format: Powder
  • Purity: 90%
  • Storage: -20℃, aviod light
  • Category: Fluorescent labeled protein
  • Molecule: Siglec-3
  • Conjugate: APC Labeled
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig­like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-­terminal Ig-­like V­-type domain, one Ig­-like C2-­type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
  • Exp Region: Asp 18 - His 259
  • Swiss-prot: AAH28152.1
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 41.5 kDa.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 41.5 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html