sc-136153 SAMPLE sc-136153
Promo Available
Scientist.com Supplier
XPF (3F2/3)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG1; XPF Antibody (3F2/3) is an IgG1 κ mouse monoclonal XPF antibody that detects XPF of mouse, rat and human origin by WB, IP and ELISA. XPF Antibody (3F2/3) is available as the non-conjugated anti-XPF antibody form, as well as multiple conjugated forms of anti-XPF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer, and it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, is a protein that associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC-1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5′ incisions during DNA repair. The ERCC1-XPF endonuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: Q92889
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, ELISA
- Human Gene Id: 2072
- Mouse Gene Id: 50505
- Protein Target: XPF
- Human Gene Name: ERCC4
- Mouse Gene Name: Ercc4
- Species Reactivity: mouse, rat, human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.