2’3’-cGAMP

DESCRIPTION

2’3’-cGAMP binds to STING (stimulator of IFN genes) and functions as an endognous second messenger to activate the innate immune system. It is produced by the cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation.

DETAILS

Purity: ≥98%
Synonyms: cGAMP, cyclic GMP-AMP, cyclic guanosine monophosphate-adenosine monophosphate, Cyclic guanosine monophosphate-adenosine monophosphate
Cas Number: 1441190-66-4
References: Li, X. D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013). Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science, 341(6152), 1390-1394. Kranzusch, P. J., Wilson, S. C., Lee, A. S., Berger, J. M., Doudna, J. A., & Vance, R. E. (2015). Ancient origin of cGAS-STING reveals mechanism of universal 2′, 3′ cGAMP signaling. Molecular cell, 59(6), 891-903. Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., ... & Chen, Z. J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science, 341(6148), 903-906.
Application: FA
Formulation: Crystalline solid
Chemical Name: 2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine
Molecular Weight: 674.4
Molecular Formula: C20H24N10O13P2
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O)O