8666430-50mg 8666430-10mg
Dorsomorphin
Biogems
DESCRIPTION
Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy.
DETAILS
- Purity: ≥98%
- Synonyms: Compound C, AMPK Inhibitor, BML-275
- Cas Number: 866405-64-3
- References: Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., ... & Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology, 4(1), 33-41. Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., ... & Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one, 3(8), e2904. Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
- Molecular Weight: 399.5
- Molecular Formula: C24H25N5O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3