PDX1 Antibody (N-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3651
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PDX1
Other Names: Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, GSF, Insulin promoter factor 1, IPF-1, Insulin upstream factor 1, IUF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, PDX1, IPF1, STF1
Availability: 2 weeks
Bio Background: PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in the gene encoding PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Bio References: Ma,J., Carcinogenesis 29 (7), 1327-1333 (2008)Watada,H., Biochem. Biophys. Res. Commun. 229 (3), 746-751 (1996)
Primary Accession: P52945
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7740a was selected from the N-term region of human PDX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.