BP7740a
PDX1 Antibody (N-term) Blocking peptide
Abcepta
DETAILS
- Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
- Gene Id: 3651
- Category: Peptides; Blocking Peptides
- Subtitle: Synthetic peptide
- Gene Name: PDX1
- Other Names: Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, GSF, Insulin promoter factor 1, IPF-1, Insulin upstream factor 1, IUF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, PDX1, IPF1, STF1
- Availability: 2 weeks
- Bio Background: PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in the gene encoding PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
- Bio References: Ma,J., Carcinogenesis 29 (7), 1327-1333 (2008)Watada,H., Biochem. Biophys. Res. Commun. 229 (3), 746-751 (1996)
- Primary Accession: P52945
- Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7740a was selected from the N-term region of human PDX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.