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sc-374431 HRP

Scientist.com Supplier

RASSF7 (C-6) HRP

Santa Cruz Biotechnology

DESCRIPTION

mouse monoclonal IgG2b; RASSF7 Antibody (C-6) is an IgG2b κ mouse monoclonal RASSF7 antibody (also designated RASSF7 antibody) that detects the RASSF7 protein of mouse, rat and human origin by WB, IP, IF and ELISA. RASSF7 Antibody (C-6) is available as both the non-conjugated anti-RASSF7 antibody form, as well as multiple conjugated forms of anti-RASSF7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Activated Ras proteins may induce senescence, apoptosis and terminal differentiation, though they are often associated with stimulating growth and transformation. Members of the RASSF family contain a highly conserved Ras association domain (RalGDS/AF-6 or RA) and function as Ras effectors/tumor suppressors. RASSF7 (Ras association domain-containing protein 7), also designated HRAS1-related cluster protein 1, is a 373 amino acid protein that localizes to the centrosome. RASSF7, RASSF8, RASSF9 and RASSF10 are four evolutionary conserved proteins that are collectively known as the N-terminal RASSF family. Expressed in skin, neural tube and eye, RASSF7 is believed to play an essential role in mitosis. Further supporting its mitotic role, knockdown of Xenopus RASSF7 has been shown to influence cell failure to form mitotic spindle and also cause nuclear breakdown and apoptosis. As a result of alternative splicing events, there are three characterized isoforms of RASSF7 that primarily differ in the C-terminus.

DETAILS

  • Host: mouse
  • Type: Primary
  • Uniprot: Q02833
  • Clonality: Monoclonal
  • Conjugate: HRP
  • Applications: WB, IHC(P), ELISA
  • Human Gene Id: 8045
  • Mouse Gene Id: 66985
  • Protein Target: RASSF7 isoforms 1 and 2
  • Human Gene Name: RASSF7
  • Mouse Gene Name: Rassf7
  • Species Reactivity: mouse, rat, human