NS 5806

DESCRIPTION

An Ito current activator; increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a KChIP2-dependent manner, in CHO-K1 cells expressing human KV4.3; increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM); reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog model of heart failure

DETAILS

Inchi: InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)
Purity: ≥98%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure
Smiles: O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1Br)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
Inchikey: UZWJWROOLOOCPQ-UHFFFAOYSA-N
Cas Number: 426834-69-7
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C16H8Br2F6N6O
Formula Weight: 574.1
Shelf Life Days: 1460