mouse monoclonal IgG1; NARG1 Antibody (D-7) is an IgG1 κ mouse monoclonal NARG1 antibody (also designated NARG1 antibody) that detects the NARG1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. NARG1 Antibody (D-7) is available as both the non-conjugated anti-NARG1 antibody form, as well as multiple conjugated forms of anti-NARG1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. NARG1 (NMDA (N-methyl-d-aspartate) receptor-regulated gene 1), also known as NATH (N-terminal acetyltransferase), TBDN100 (tubedown-1) or Ga19 (Gastric cancer antigen Ga19), is a cytoplasmic protein that contains eight TPR repeats. NARG1 is expressed at high levels in dividing tissues such as bone marrow, testis and embryonal brain and it is overexpressed in papillary thyroid carcinomas. NARG1 interacts with ARD1 or ARD2 forming a complex that exhibits N-terminal (alpha) acetyltransferase activity. The complex interacts with ribosomal subunits functioning in cotranslational acetylation. During apoptosis, both NARG1 and ARD1 are cleaved by caspases which results in decreased acetyltransferase activity. Knockdown of NARG1 in HeLa cells leads to apoptosis, indicating that properly functioning NARG1 is essential for cell viability. In addition, this suggests NARG1 as a potential target in cancer therapy.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.