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CT4-H52A4-100ug CT4-H52A4-1mg

Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin

ACROBiosystems

DESCRIPTION

Human CTLA-4 Protein, Mouse IgG2a Fc Tag (CT4-H52A4) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1).

DETAILS

  • Tag: C-mFc(mIgG2a)
  • Host: HEK293
  • Size: 100ug
  • Buffer: 50 mM Tris, 100 mM Glycine, pH7.5
  • Format: Powder
  • Purity: 95%
  • Storage: -20℃
  • Category: Immune Checkpoint Proteins
  • Molecule: CTLA-4
  • Accession: NP_005205.2
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Background: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
  • Exp Region: Ala 37 - Phe 162
  • Swiss-prot: P16410-1
  • Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa under non-reducing (NR) condition.
  • Endotoxin Level: 0.1 EU per μg
  • Molecular Weight: 40.6 kDa
  • Shipping Condition: RT
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html