Niguldipine (hydrochloride)

DESCRIPTION

A dihydropyridine that acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM); less potently blocks L- and T-type Ca2+ channels (IC50s = 0.4 and 0.9 µM, respectively)

DETAILS

Inchi: InChI=1S/C36H39N3O6.ClH/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29;/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3;1H
Purity: ≥98%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area
Smiles: O=C(C(C(C1=CC([N+]([O-])=O)=CC=C1)C(C(OC)=O)=C(C)N2)=C2C)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.Cl
Inchikey: MHOSUIMBPQVOEU-UHFFFAOYSA-N
Cas Number: 119934-51-9
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C36H39N3O6 • HCl
Formula Weight: 646.2
Shelf Life Days: 1460