DR6 Antibody

DETAILS

Buffer: DR6 Antibody is supplied in PBS containing 0.02% sodium azide.
Isotype: IgG
Storage: DR6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Category: Antibody
Homology: Predicted species reactivity based on immunogen sequence: Rat: (73%), Mouse: (73%)
Shipping: Blue Ice
Clonality: Polyclonal
Conjugate: Unconjugated
Immunogen: DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6.The immunogen is located within amino acids 30 - 80 of DR6.
Swissprot: O75509
User Note: Optimal dilutions for each application to be determined by the researcher.
Background: DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Host Species: Rabbit
Ncbi Gene Id: 27242
Purification: DR6 Antibody is DEAE purified.
Concentration: 1 mg/ml
Modifications: None
Ncbi Organism: Homo sapiens
Physical State: Liquid
Additional Names: DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
Application Note: DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
By Research Area: Apoptosis
Protein Accession: AF068868
Protein Gi Number: 3549262
Ncbi Official Name: tumor necrosis factor receptor superfamily, member 21
Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate
Positive Control 2: Cat. No. 1204 - K562 Cell Lysate
Species Reactivity: Human
Tested Applications: ELISA,WB
Ncbi Official Symbol: TNFRSF21
Predicted Molecular Weight: 68 kDa