35-1686-50 35-1686
Polyclonal Antibody to MDM2
Abeomics
Image
DESCRIPTION
MDM2, a ubiquitin igase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .
DETAILS
- Gene: MDM2
- App Id: WB
- Antigen: MDM2
- Gene Id: 4193
- Isotype: Rabbit IgG
- Format Id: Purified
- Uniprot Id: Q00987
- Host Animal: Rabbit
- Clonality Id: Polyclonal
- Reactivity Id: Human
- Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- Alternative Name: HDMX|| hdm2
- Application Note: Predicted MW: 90kd, Western blotting: 1:500~1:1000
- Storage Condition: Store the antibody at 4°C, stable for 6 months. For ong-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: Peptide sequence around aa.18~22(Q-I-P-A-S) derived from Human MDM2.