mouse monoclonal IgG1; CARP-1 Antibody (E-4) is an IgG1 κ mouse monoclonal CARP-1 antibody (also designated CARP-1 antibody) that detects the CARP-1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CARP-1 Antibody (E-4) is available as both the non-conjugated anti-CARP-1 antibody form, as well as multiple conjugated forms of anti-CARP-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CARP-1 (cell division cycle and apoptosis regulator 1), also known as CCAR1 or DIS, is a 1,150 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one SAP domain. Expressed in several epithelial cancer cell lines, including breast, colon, prostate and leukemia, CARP-1 is involved in apoptotic signaling, as well as in cell cycle progression and cell proliferation via interaction with c-Myc and cyclin B1. CARP-1 is subject to DNA damage-induced phosphorylation, probably by ATM or ATR. The gene encoding CARP-1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie-Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.