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Recombinant Human/Murine/Rat BDNF



BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.


  • Gene Id: 627
  • Uniprot: P23560
  • Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
  • Category: RUO Cytokines
  • Subcategory: Neurotrophins
  • Research Areas: Neurobiology, Stem Cells and Differentiation, Organoids
  • Alternative Names: Brain Derived Neurotrophic Factor, Abrineurin
  • Species of Origin: Human/Murine/Rat
  • Expression System Source: E.coli