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Human G1/S-specific Cyclin-D1, CYCLIN-D1 ELISA Kit

Bioassay Technology Laboratory


Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.


  • GeneID: 595
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 33,729
  • Synonyms: B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;CCND 1;CCND1;G1/S-specific cyclin-D1;PRAD1 oncogene
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: CCND1
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.052ng/ml
  • Target Protein: CCND1
  • Detection Range: 0.1-40ng/ml
  • Full Product Name: G1/S-Specific Cyclin-D1
  • Standard Solution: 48ng/ml
  • UniProt Accession: P24385