200-04
Scientist.com Supplier
Recombinant Human IL-4
PeproTech
DESCRIPTION
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
DETAILS
- Gene Id: 3565
- Uniprot: P05112
- Activity: The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
- Category: RUO Cytokines
- Subcategory: Growth Factors & Cytokines
- Research Areas: Apoptosis, Cancer, Cell Culture, Immune System, Inflammation, Stem Cells and Differentiation, Allergy, Transplantation, Organoids, COVID-19
- Alternative Names: BCGF, BCDF, B cell stimulating factor (BSF-1)
- Species of Origin: Human
- Expression System Source: E.coli
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