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Recombinant Human IL-4



IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.


  • Gene Id: 3565
  • Uniprot: P05112
  • Activity: The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Apoptosis, Cancer, Cell Culture, Immune System, Inflammation, Stem Cells and Differentiation, Allergy, Transplantation, Organoids, COVID-19
  • Alternative Names: BCGF, BCDF, B cell stimulating factor (BSF-1)
  • Species of Origin: Human
  • Expression System Source: E.coli