Olomoucine II

DESCRIPTION

A CDK inhibitor (IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 µM for Cdk1, -2, -4, -7, and -9, respectively); selective for CDKs over 10 additional kinases (IC50s = >100 µM for all) but does inhibit ERK2 (IC50 = 32 µM) and ABCB1(IC50 = 6.4 µM); inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 µM, respectively); inhibits replication of HSV-1, HSV-2, vaccinia virus, Ad4, and human CMV (IC50s = 5, 4.7, 3.8, 2.4, 3.2 µM, respectively)

DETAILS

Inchi: InChI=1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)/t14-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV
Smiles: OC[C@H](NC1=NC(NCC2=C(O)C=CC=C2)=C3N=CN(C(C)C)C3=N1)CC
Inchikey: NDUVSANREQEDRE-CQSZACIVSA-N
Cas Number: 500735-47-7
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C19H26N6O2
Formula Weight: 370.5
Shelf Life Days: 1460