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36-3497-20 36-3497-100

Scientist.com Supplier

Anti-Aurora B (Proliferation Marker) Monoclonal Antibody(Clone: AURKB/1521)

Abeomics

DESCRIPTION:
Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

DETAILS

  • Gene: AURKB
  • App Id: WB
  • Gene Id: 9212
  • Isotype: Mouse IgG1, kappa
  • Clone Name: AURKB/1521
  • Uniprot Id: Q96GD4
  • Host Animal: Mouse
  • Clonality Id: Monoclonal
  • Reactivity Id: Human
  • Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  • Alternative Name: AIK2; AIM-1; ARK-2; AurB; AURKB; Aurora-1; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48 (PPP1R48); Serine/threonine-protein kinase 12; Serine/threonine-protein ki
  • Application Note: Western Blot (1-2ug/ml);
  • Categories Name 1: Antibodies
  • Categories Name 2: Cancer Marker
  • Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
  • Immunogen Information: Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)