Anti-CD3 Antibody [JE80-02]

DESCRIPTION

The CD3 protein is a T-cell marker, a complex of four structurally distinct membrane glycoprotein isoforms, 20-50 kDa, comprising extracellular, transmembrane and intracellular domains. The CD3 complex is responsible for mediating signal transduction to the internal environment upon antigenic recognition by TCR, causing T-cell proliferation and release of cytokines. Except for a weak expression in Purkinje cells (with some of the Abs) and activated NK-cells, CD3 is found only in T-cells. CD3 appear in the cytoplasm of prothymocytes, and on the surface of about 95% of thymocytes, while cytoplasmic CD3 is lost as the cells differentiate into medullary thymocytes. In therapy resistant celiac disease, a shift from membranous to cytoplasmic CD3 expression is seen (together with loss of CD8). In malignant lymphomas, CD3 is a pan-T-cell lineage-restricted antigen, detected in 80-97% of the T-cell lymphomas. Mature T-cell lymphomas including cases of mycosis fungoides, peripheral T-cell lymphoma and anaplastic large cell lymphoma may aberrantly lose CD3. NK-cell lymphomas can show a cytoplasmic reaction. Reed-Sternberg cells may show a globular paranuclear reaction. CD3 is an important marker in the classification of malignant lymphomas and lymphoid leukaemias. Also the marker is useful for the identification of T-cells in, e.g., celiac disease, lymphocytic colitis and colorectal carcinomas associated with loss of a mismatch repair protein.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: P07766 Human;SwissProt: P04234 Human;SwissProt: P09693 Human;SwissProt: P20963 Human
Clone Id: JE80-02
Clonality: Recombinant Rabbit monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: 4930549J05Rik antibody A430104F18Rik antibody AW552088 antibody Cd247 antibody CD247 antigen antibody CD247 antigen, zeta subunit antibody CD247 molecule antibody CD3 antibody CD3 antigen, delta subunit antibody CD3 delta antibody CD3 epsilon antibody CD3 eta antibody CD3 gamma antibody CD3 molecule delta polypeptide antibody CD3 molecule, epsilon polypeptide antibody CD3 molecule, gamma polypeptide antibody CD3 zeta antibody CD3-DELTA antibody CD3d antibody CD3D antigen delta polypeptide antibody CD3d antigen, delta polypeptide (TiT3 complex) antibody CD3d molecule delta antibody CD3d molecule delta CD3 TCR complex antibody CD3d molecule, delta (CD3-TCR complex) antibody CD3D_HUMAN antibody CD3E antibody CD3e antigen antibody CD3E antigen epsilon polypeptide antibody CD3e antigen, epsilon polypeptide (TiT3 complex) antibody CD3e molecule epsilon antibody CD3e molecule epsilon CD3 TCR complex antibody CD3e molecule, epsilon (CD3-TCR complex) antibody CD3epsilon antibody CD3G antibody CD3g antigen antibody CD3G antigen gamma polypeptide antibody CD3g antigen, gamma polypeptide (TiT3 complex) antibody CD3g molecule gamma antibody CD3g molecule gamma CD3 TCR complex antibody CD3g molecule, gamma (CD3-TCR complex) antibody CD3H antibody CD3Q antibody CD3Z antibody CD3zeta antibody Ctg3 antibody FLJ17620 antibody FLJ17664 antibody FLJ18683 antibody FLJ79544 antibody FLJ94613 antibody IMD19 antibody Leu-4 antibody MGC138597 antibody OKT3, delta chain antibody OTTHUMP00000032544 antibody T cell receptor antibody T cell receptor T3 delta chain antibody T cell receptor T3 gamma chain antibody T cell receptor T3 zeta chain antibody T cell receptor zeta chain antibody T cell surface antigen T3/Leu 4 epsilon chain antibody T cell surface glycoprotein CD3 antibody T cell surface glycoprotein CD3 delta chain antibody T cell surface glycoprotein CD3 epsilon chain antibody T cell surface glycoprotein CD3 gamma chain antibody T cell surface glycoprotein CD3 zeta chain antibody T-cell antigen receptor complex, delta subunit of T3 antibody T-cell antigen receptor complex, epsilon subunit of T3 antibody T-cell antigen receptor complex, gamma subunit of T3 antibody T-cell antigen receptor complex, zeta subunit of CD3 antibody T-cell receptor T3 delta chain antibody T-cell receptor T3 gamma chain antibody T-cell surface antigen T3/Leu-4 epsilon chain antibody T-cell surface glycoprotein CD3 delta chain antibody T-cell surface glycoprotein CD3 epsilon chain antibody T-cell surface glycoprotein CD3 gamma chain antibody T3 antibody T3d antibody T3e antibody T3g antibody T3z antibody TCRE antibody TCRk antibody Tcrz antibody TCRzeta antibody
Application: WB,IHC-P,IF-Tissue,IP
Epitope Region: Synthetic peptide within human CD3E aa 158-207/207.
Protein Target: CD3E
Target Species: Human
Species Reactivity: Human