Human IL-18 Protein, premium grade

DESCRIPTION

Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-gamma (IFN-gamma) production from Th1 cells, NK cells and activated macrophages, particularly in the presence of IL-12. IL-18 also functions in developmental regulation of T-lymphocyte helper type I cells and in Fas-mediated cytotoxicity. Suppression of IL-18 activity is being investigated for treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. It acts by inducing heterodimerization of the two subunits of its receptor, IL-18RAlpha and IL-18RBeta shows structural similarity to IL-1.

DETAILS

Tag: Native
Host: E. coli
Size: 20ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human IL-18 Protein, premium grade (IL8-H5114) is expressed from E. coli cells. It contains AA Tyr 37 - Asp 193 (Accession # Q14116-1).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: IL-18
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 24 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Tyr 37 - Asp 193
Package Size: 20ug*1
Characteristics: This protein carries no "tag". The protein has a calculated MW of 18.2 kDa. The protein migrates as 16 kDa±3 kDa under reducing (R) condition, and 16 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE)
Endotoxin Level: 0.01 EU per μg
Molecular Weight: 18.2 kDa
Shipping Condition: RT
Species Reactivity: Human
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