mouse monoclonal IgG2a; GUF1 Antibody (B-7) is an IgG2a κ mouse monoclonal GUF1 antibody (also designated GUF1 antibody) that detects the GUF1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. GUF1 Antibody (B-7) is available as both the non-conjugated anti-GUF1 antibody form, as well as multiple conjugated forms of anti-GUF1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. GUF1 (GUF1 GTPase), also known as EF-4 (elongation factor 4 homolog), translation factor GUF1 (mitochondrial), ribosomal back-translocase or GTPase of unknown function 1, is a 669 amino acid protein belonging to the GTP-binding elongation factor family and the LepA subfamily. Localizing to the mitochondrion inner membrane, GUF1 is thought to promote mitochondrial protein synthesis and binds to mitochondrial ribosomes in a GTP-dependent manner. GUF1 is suggested to catalyze a one-codon backward translocation of tRNAs on improperly translocated ribosomes, thereby acting as a fidelity factor of the translation reaction. GUF1 is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene desert (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.