35-1612-50 35-1612-100
Scientist.com Supplier
Polyclonal Antibody to PKR (Ab-451)
Abeomics
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DESCRIPTION
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Ingrid K. Ruf, et,al. (2005) J. Virol ; 79: 14562 - 14569.
Christy M. Hebner,et,al. (2006) J. Gen. Virol ; 87: 3183 - 3193.
Rika van Huizen, et,al. (2003) J. Biol. Chem ; 278: 15558 - 15564.
DETAILS
- Gene: EIF2AK2
- App Id: IHC,IF
- Antigen: PKR (Ab-451)
- Gene Id: 5610
- Isotype: Rabbit IgG
- Format Id: Purified
- Uniprot Id: P19525
- Host Animal: Rabbit
- Clonality Id: Polyclonal
- Reactivity Id: Human
- Product Content: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- Alternative Name: ADRB2|| E2AK2|| EIF2AK2|| EIF2aK|| PRKR
- Application Note: Predicted MW: 68kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
- Categories Name 1: Antibodies
- Categories Name 2: Cell Signalling
- Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: Peptide sequence around aa.449~453 (K-G-T-L-R) derived from Human PKR.
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