Human Mothers Against Decapentaplegic Homolog 7, SMAD7 ELISA Kit

DESCRIPTION

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

DETAILS

GeneID: 4092
Species: Human
Storage: 2-8ºC
MASS(Da): 46,426
Synonyms: hSMAD7;MAD homolog 7;MAD homolog 8;Mothers against decapentaplegic homolog 7;Mothers against decapentaplegic homolog 8;Mothers against DPP homolog 7;Mothers against DPP homolog 8;SMAD 7;SMAD family member 7;SMAD7
Assay Time: 1h 30m
Assay Type: Sandwich
Gene Names: SMAD7
Reactivity: Human
Sample Type: Serum, plasma, cell culture supernates
Sensitivity: 0.022ng/ml
Target Protein: SMAD7
Detection Range: 0.05-20ng/ml
Full Product Name: Mothers Against Decapentaplegic Homolog 7
Standard Solution: 24ng/ml
UniProt Accession: O15105