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Animal-Free Recombinant Human Vitronectin



Vitronectin is a secreted glycoprotein that is synthesized in the liver. It circulates primarily in monomeric form, but can undergo conformational change to a structure that forms disulfide-linked multimers. The multimeric vitronectin can efficiently bind to, and incorporate into, the extracellular matrix. Within the matrix, vitronectin can support cell adhesion through binding to various integrins and other proteoglycans. Additionally, recombinant vitronectin can function as a chemically-defined matrix component in human embryonic stem cell renewal media. Recombinant Human Vitronectin is a 459 amino acid, single-chain, monomeric protein, which migrates at an apparent molecular weight of 75 kDa by SDS-PAGE under reducing conditions. The calculated molecular weight of Recombinant Human Vitronectin is 52.2 kDa.


  • Gene Id: 7448
  • Uniprot: P04004
  • Activity: Recombinant human Vitronectin promotes attachment of hESC and iPSC in serum-free, feeder conditions at 5ug/ml.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: Immune System, Neurobiology, Stem Cells and Differentiation
  • Alternative Names: VTN, Serum-spreading factor, V75
  • Species of Origin: Human
  • Expression System Source: HEK293 cells