TrkA Assay Kit

DESCRIPTION

The tropomyosin receptor kinases (TRK) are a family of tyrosine receptor kinases, which include TrkA, TrkB and TrkC. TrkA is activated by binding to nerve growth factor (NGF), resulting in activation of cell proliferation through the RAS/MAPK/ERK and PLCγ/PI3K pathways. Constitutive activation of TrkA is associated with colorectal cancer, suggesting TrkA inhibitors may have potential therapeutic value. The TrkA Assay Kit is designed to measure TrkA activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The TrkA Assay Kit comes in a convenient 96-well format, with enough purified recombinant TrkA enzyme, TrkA substrate, ATP and kinase assay buffer for 100 enzyme reactions.

DETAILS

Shiptemp: -80°C (dry ice)
Category: Kinase/Assay Kit
Description: The tropomyosin receptor kinases (TRK) are a family of tyrosine receptor kinases, which include TrkA, TrkB and TrkC. TrkA is activated by binding to nerve growth factor (NGF), resulting in activation of cell proliferation through the RAS/MAPK/ERK and PLCγ/PI3K pathways. Constitutive activation of TrkA is associated with colorectal cancer, suggesting TrkA inhibitors may have potential therapeutic value. The TrkA Assay Kit is designed to measure TrkA activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The TrkA Assay Kit comes in a convenient 96-well format, with enough purified recombinant TrkA enzyme, TrkA substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Methodology: Chemiluminescent
Unspsc Code: 41105332
Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Product Type: Assay Kit
Biosafety Level: Not applicable (BSL-1)
Related Products: 40282, 40281, 40280, 79798, 78487
Storage Stability: Up to 6 months when stored as recommended
Scientific Category: Kinase