MERTK Antibody (N-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 10461
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MERTK
Other Names: Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK, MER
Availability: 2 weeks
Bio Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Bio References: Thompson, D.A., et al., Am. J. Hum. Genet. 70(1):224-229 (2002).Graham, D.K., et al., Cell Growth Differ. 5(6):647-657 (1994).Weier, H.U., et al., Cytogenet. Cell Genet. 84 (1-2), 91-92 (1999).
Primary Accession: Q12866
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7662a was selected from the N-term region of human MERK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.