LTK Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 4058
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: LTK
Other Names: Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, LTK, TYK1
Availability: 2 weeks
Bio Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Bio References: Toyoshima, H., et al., Proc. Natl. Acad. Sci. U.S.A. 90(12):5404-5408 (1993).Krolewski, J.J., et al., EMBO J. 10(10):2911-2919 (1991).Maru, Y., et al., Oncogene Res. 5(3):199-204 (1990).
Primary Accession: P29376
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7658b was selected from the C-term region of human LTK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.