120-36
Recombinant Human SPARC/Osteonectin
PeproTech
DESCRIPTION
SPARC/Osteonectin is a secreted, evolutionarily-conserved, collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains: an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Recombinant Human SPARC/Osteonectin is a glycoprotein containing 286 amino acids that migrates at an apparent MW of 43.7 kDa by SDS-PAGE analysis due to the effect of glycosylation. The calculated molecular weight of Recombinant Human SPARC/Osteonectin is 32.7 kDa.
DETAILS
- Gene Id: 6678
- Uniprot: P09486
- Activity: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3 cells, with an IC50 of 0.5-0.7 ug/ml.
- Category: RUO Cytokines
- Subcategory: Growth Factors & Cytokines
- Research Areas: Angiogenesis/Cardiovascular, Bone, Skeletal, Cartilage, Cancer, Immune System, Wound Healing
- Alternative Names: Secreted protein acidic and rich in cysteine, BM-40, ON
- Species of Origin: Human
- Expression System Source: CHO cells
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