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PluriSln 1
Biogems
DESCRIPTION
PluriSln 1 a stearoyl-CoA desaturase 1 (SCD1) inhibitor used to selectively eliminate undifferentiated human pluripotent stem cells. It induces apoptosis in hPSCs to the exclusion of differentiated or progenitor cells. It is reported to prevent teratoma formation in immunocompromised mice.
DETAILS
- Purity: ≥95%
- Synonyms: NSC 14613, 4-Pyridinecarboxylicacid, 2-phenylhydrazide
- Cas Number: 91396-88-2
- References: Ben-David, U., Gan, Q. F., Golan-Lev, T., Arora, P., Yanuka, O., Oren, Y. S., ... & Benvenisty, N. (2013). Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.Cell Stem Cell, 12(2), 167-179. Phillips, M. I. (2014). Tumor-free iPS stem cells for heart cells. Cell Cycle,13(10), 1519-1519. Lou, K. J. (2013). Small molecules vs. teratomas. SciBX: Science-Business eXchange, 6(7).
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: N'-phenylpyridine-4-carbohydrazide
- Molecular Weight: 213.2
- Molecular Formula: C12H11N3O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2