Anti-KMT3B Antibody [1B1]

DESCRIPTION

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: Q96L73 Human
Clone Id: 1B1
Clonality: Recombinant Rabbit monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: Androgen receptor coactivator 267 kDa protein antibody Androgen receptor-associated protein of 267 kDa antibody ARA267 antibody H3 K36 HMTase antibody H3-K36-HMTase antibody H4 K20 HMTase antibody H4-K20-HMTase antibody Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody KMT3B antibody Lysine N-methyltransferase 3B antibody NR binding SET domain containing protein antibody NR-binding SET domain-containing protein antibody Nsd1 antibody NSD1_HUMAN antibody Nuclear receptor binding SET domain containing protein 1 antibody Nuclear receptor binding SET domain protein 1 antibody Nuclear receptor-binding SET domain-containing protein 1 antibody
Application: IF-Cell
Epitope Region: Recombinant protein within Human KMT3B aa 1-200 / 2,696.
Protein Target: NSD1
Target Species: Human
Species Reactivity: Human