31140
PHIP (BD1), His-tag Recombinant
BPS Bioscience
DESCRIPTION
Human bromodomain pleckstrin homology domain interacting protein (PHIP), also known as IRS-1 PH Domain-Binding Protein, WDR11, and BRWD2, GenBank Accession No. NM_017934, a.a. 1146 - 1287 corresponding to bromodomain 1, with N-terminal His-tag, MW = 17 kDa, expressed in an E. coli cell expression system.
DETAILS
- Aa: 1146 - 1287
- Mw: 17 kDa
- Tags: N-terminal His-tag
- Format: Aqueous buffer solution
- Genbank: NM_017934
- Species: Human
- Uniprot: Q8WWQ0
- Shiptemp: -80°C (dry ice)
- Synonyms: bromodomain pleckstrin homology domain interacting protein, IRS-1 PH Domain-Binding Protein, WDR11, BRWD2
- Warnings: Avoid freeze/thaw cycles.
- Category: Bromodomain/Protein
- Background: PHIP is a bromodomain-containing protein that binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1 ), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival. It stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation.
- References: 1. De Semir, D., et al., Proc. Natl. Acad. Sci. USA. 2012 May 1;109(18):7067-72.2. Farhang-Fallah, J., et al., J. Biol. Chem. 2000 Dec 22;275(51):40492-7.
- Description: Human bromodomain pleckstrin homology domain interacting protein (PHIP), also known as IRS-1 PH Domain-Binding Protein, WDR11, and BRWD2, GenBank Accession No. NM_017934, a.a. 1146 - 1287 corresponding to bromodomain 1, with N-terminal His-tag, MW = 17 kDa, expressed in an E. coli cell expression system.
- Formulation: 40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
- Unspsc Code: 12352202
- Unspsc Name: Proteins
- Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
- Product Type: Protein
- Biosafety Level: Not applicable (BSL-1)
- Storage Stability: Store at -80°C. Stable for >6 months when stored as directed.
- Scientific Category: Bromodomain