DCPIB

DESCRIPTION

A VRAC inhibitor; inhibits ICl,swell in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM); inhibits LRRC8A (IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in TIME cells at 20 µM; inhibits K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively); activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels at 10 µM; intracisternal administration reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by MCAO at 20 µg/kg

DETAILS

Inchi: InChI=1S/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26)
Purity: ≥98%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease||Research Area|Neuroscience|Neuroprotection|Ischemia
Smiles: O=C(CCCOC1=C(Cl)C(Cl)=C(C(C(CCCC)(C2CCCC2)C3)=O)C3=C1)O
Inchikey: KHKGTPJPBOQECW-UHFFFAOYSA-N
Cas Number: 82749-70-0
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C22H28Cl2O4
Formula Weight: 427.4
Shelf Life Days: 1460