30-2669
Anti-Human CD100 PE (Clone : 133-1C6)
Abeomics
DESCRIPTION
CD100, also known as Semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.Specificity : The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100, an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes, NK cells, monocytes/macrophages and granulocytes, but also on some non-hematopoietic cells.
DETAILS
- Gene: SEMA4D
- App Id: FACS
- Antigen: CD100
- Gene Id: 10507
- Isotype: Mouse IgM
- Clone Name: 133-1C6
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Purification: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivity Id: Human
- Product Content: Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
- Alternative Name: COLL4, SEMA4D, semaphorin 4D,semaphorin 4D
- Application Note: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: PHA stimulated human PBL
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