6861787-10mg 6861787-1mg
IWP-4
Biogems
DESCRIPTION
IWP-4 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.
DETAILS
- Purity: ≥95%
- Synonyms: Inhibitor of Wnt Production-4
- Cas Number: 686772-17-8
- References: Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Hudson, J., Titmarsh, D., Hidalgo, A., Wolvetang, E., & Cooper-White, J. (2011). Primitive cardiac cells from human embryonic stem cells. Stem cells and development, 21(9), 1513-1523. Bilir, B., Kucuk, O., & Moreno, C. S. (2013). Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med, 11(1), 280.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
- Molecular Weight: 496.6
- Molecular Formula: C23H20N4O3S3
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5OC)SCC4