6-Methylsulfinylhexyl isothiocyanate

DESCRIPTION

An isothiocyanate with diverse biological activities; inhibits NO production in mouse peritoneal exudate macrophages at 5 µM; inhibits arachidonic acid-induced aggregation of isolated human platelets (IC50 = 21.9 µM); reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM); reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of 6-OHDA-induced Parkinson's disease at 5 mg/kg twice weekly; reduces the number of lung metastases in a B16/F10 murine melanoma model

DETAILS

Inchi: InChI=1S/C8H15NOS2/c1-12(10)7-5-3-2-4-6-9-8-11/h2-7H2,1H3
Purity: ≥98%
Raptas: Product Type|Biochemicals|Natural Products|Isothiocyanates||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease
Smiles: S=C=NCCCCCCS(C)=O
Inchikey: XQZVZULJKVALRI-UHFFFAOYSA-N
Cas Number: 4430-35-7
Formulation: A solution in ethanol
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C8H15NOS2
Formula Weight: 205.3
Shelf Life Days: 730