ANTXR1 Antibody (Y382) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 84168
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ANTXR1
Other Names: Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Availability: 2 weeks
Bio Background: ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Bio References: Werner,E., J. Biol. Chem. 281 (32), 23227-23236 (2006)Wei,W., Cell 124 (6), 1141-1154 (2006)Rainey,G.J., Proc. Natl. Acad. Sci. U.S.A. 102 (37), 13278-13283 (2005)
Primary Accession: Q9H6X2
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7746a was selected from the Y382 region of human ANTXR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.