Mouse Rnasen Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 14000
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: Drosha
Other Names: Ribonuclease 3, Protein Drosha, Ribonuclease III, RNase III, Drosha, Etohi2, Rn3, Rnasen
Availability: 2 weeks
Bio Background: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, RNASEN/DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies (By similarity).
Bio References: Chong, M.M., et al. Genes Dev. 24(17):1951-1960(2010)Yang, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15163-15168(2010)Michon, F., et al. Dev. Biol. 340(2):355-368(2010)Wu, H., et al. PLoS ONE 4 (10), E7566 (2009) :Shenoy, A., et al. PLoS ONE 4 (9), E6971 (2009) :
Primary Accession: Q5HZJ0