p1580-31t p1580-31
Promo Available
Anti-Tyrosine Hydroxylase (Ser31) Antibody
PhosphoSolutions
DESCRIPTION
Our Anti-Tyrosine Hydroxylase (Ser31) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat Tyrosine Hydroxylase (Ser31) and is antigen affinity purified from pooled serum. It is great for use in WB, IHC, ICC.
DETAILS
- Form: Antigen Affinity Purified from Pooled Serum
- Gene: TH
- Host: Rabbit
- Rrid: AB_2492278
- Type: Primary Antibody
- Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
- Target: Tyrosine Hydroxylase (Ser31)
- Isotype: IgG
- Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- Shipping: Blue Ice
- Synonyms: Dystonia 14 antibody, DYT14 antibody, DYT5b antibody, EC 1.14.16.2 antibody, OTTHUMP00000011225 antibody, OTTHUMP00000011226 antibody, ple antibody, Protein Pale antibody, TH antibody, The antibody, TY3H_HUMAN antibody, TYH antibody, Tyrosine 3 hydroxylase antibody, Tyrosine 3 monooxygenase antibody, Tyrosine 3-hydroxylase antibody, Tyrosine 3-monooxygenase antibody, Tyrosine hydroxylase antibody
- Clonality: Polyclonal
- Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser31 of rat tyrosine hydroxylase, conjugated to keyhole limpet hemocyanin (KLH).
- Expiration: After date of receipt, stable for at least 1 year at -20°C.
- Specificity: Specific for endogenous levels of the ~60 kDa tyrosine hydroxylase protein phosphorylated at Ser31.
- Applications: WB, IHC, ICC
- Ncbi Gene Id: 25085
- Conjugate Exem: Unconjugated
- Physical State: Liquid
- Quality Control: Western blots performed on each lot.
- Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
- Molecular Weight: 60
- Production Notes: Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
- Dilution Range Wb: 1:1000
- Immunogen Species: Rat
- Dilution Range Icc: 1:50-1:300
- Dilution Range Ihc: 1:300-1:1000
- Species Reactivity: Human, Mouse, and Rat
- Target Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.
- Expected Reactivity: Non-Human Primate
- Dilution Range Wb Brain: 1:1000
- Uniprot Number Immunogen Species: P04177
- Post Translational Modification Type: Phosphorylated
- Post Translational Modification Residue: Ser31
PROMOTION TERMS
Trial Size Available. Limit 1
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