Animal-Free Recombinant Rat TPO

DESCRIPTION

TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. Recombinant Rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

DETAILS

Gene Id: 81811
Uniprot: P49745
Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
Category: RUO Cytokines
Subcategory: Animal-Free Cytokines
Research Areas: Cell Culture, Immune System, Stem Cells and Differentiation, Wound Healing
Alternative Names: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Species of Origin: Rat
Expression System Source: E.coli