mouse monoclonal IgG1; Tom40 Antibody (D-2) is an IgG1 κ mouse monoclonal Tom40 antibody (also designated Translocase Of Outer Mitochondrial Membrane 40 antibody, C19orf1 antibody, PEREC1 antibody, Translocase Of Outer Membrane 40 KDa Subunit Homolog antibody, Mitochondrial Import Receptor Subunit TOM40 Homolog antibody, Translocase Of Outer Mitochondrial Membrane 40 Homolog (Yeast) antibody, Translocase Of Outer Mitochondrial Membrane 40 Homolog antibody, or Mitochondrial Outer Membrane Protein antibody) that detects the Tom40 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Tom40 Antibody (D-2) is available as both the non-conjugated anti-Tom40 antibody form, as well as multiple conjugated forms of anti-Tom40 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The mitochondrial preprotein translocases of the outer membrane (Tom) is a multisubunit protein complex that facilitates the import of nucleus-encoded precursor proteins across the mitochondrial outer membrane. The Tom machinery consists of import receptors for the initial binding of cytosolically synthesized preproteins and a general import pore (GIP) for the membrane translocation of various preproteins into the mitochondria. The import receptors include Tom20 and Tom22, which form a heteromeric receptor complex that initiates the insertion of newly synthesized proteins into the outer membrane and then directs the precursor protein into the GIP. In yeast, Tom22 is the essential component of the import receptor complex as it functions as both a receptor for the preproteins and serves as a docking point for both Tom20 and the GIP. Tom22 directly associates with Tom40, the major component of the GIP, and thereby forms a stable interaction between the two core complexes to facilitate the fluid movement of preproteins into the mitochondria. The insertion of Tom40 into the Tom machinery requires the initial binding of Tom40 to Tom20 and leads to the efficient incorporation of Tom40 precursors into preexisting Tom complexes (2,8)

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.