RP02164
Recombinant Human SLAMF5/CD84 Protein
ABclonal
DESCRIPTION
SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-γproduction, and the interactions between T cells and B cells that are required for germinal center formation.
DETAILS
- Tag: C-His
- Source: HEK293 cells
- Gene Id: 8832
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q9UIB8
- Research Areas: Immune Checkpoint,Bio-Markers & CD Antigens
- Alternative Names: CD84, LY9B, SLAMF5, hCD84, mCD84, CD84 molecule,LY9B,SLAMF5,hCD84,mCD84
Equivalent Items
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