1956772-25mg 1956772-10mg
BAY 11-7082
Biogems
DESCRIPTION
Bay 11-7082 is a selective and irreversible inhibitor of TNF alpha induced IκBα phosphorylation and the binding of ubiquitin. It is reported to induce apoptosis in several B and T lymphoma cell lines and TNF-alpha induced expression of several adhesion molecules.
DETAILS
- Purity: ≥98%
- Synonyms: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
- Cas Number: 19542-67-7
- References: Mori, N., Yamada, Y., Ikeda, S., Yamasaki, Y., Tsukasaki, K., Tanaka, Y., ... & Fujii, M. (2002). Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I–infected T-cell lines and primary adult T-cell leukemia cells. Blood, 100(5), 1828-1834. Lappas, M., Yee, K., Permezel, M., & Rice, G. E. (2005). Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-κB and IκB kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology, 146(3), 1491-1497. García, M. G., Alaniz, L., Lopes, E. C., Blanco, G., Hajos, S. E., & Alvarez, E. (2005). Inhibition of NF-κB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leukemia research, 29(12), 1425-1434.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: (E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
- Molecular Weight: 207.3
- Molecular Formula: C10H9NO2S
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=CC=C(C=C1)S(=O)(=O)C=CC#N