mouse monoclonal IgG1; OSR2 Antibody (H-8) is an IgG1 κ mouse monoclonal OSR2 antibody (also designated OSR2 antibody) that detects the OSR2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. OSR2 Antibody (H-8) is available as both the non-conjugated anti-OSR2 antibody form, as well as multiple conjugated forms of anti-OSR2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. OSR (Odd-skipped related) proteins belong to the Odd C2H2-type zinc-finger protein family and are involved in embryonic development and bone formation. OSR2 (odd-skipped related 2) is a 312 amino acid protein that contains five zinc finger domains. It is expressed in the kidneys, skeletal muscle, testis, and mouse embryos and may be involved in transcriptional activity and osteoblast function. The expression of OSR2 is regulated by C/EBP regulatory elements. OSR2 plays a role in regulating palatal development and expression of alkaline phosphatase. Two isoforms, OSR2A and OSR2B, are produced due to alternative splicing. OSR2B is 36 amino acids shorter than OSR2A and contains only three zinc finger motifs. Both isoforms localize to the nucleus and are thought to exhibit opposite transcriptional activities. Mutations in the gene encoding OSR2 can alter the gene expression of Pax-9 and TGFβ3.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.