2783097-10mg 2783097-1mg
GW 4064
Biogems
DESCRIPTION
GW 4064 is a selective and potent agonist of the Farnesoid X receptor, a regulator of bile acid and lipid homeostasis. It does not react with the retinoic acid receptor at concentrations of up to 1uM.
DETAILS
- Purity: ≥95%
- Synonyms: GW-4064, GW4064
- Cas Number: 278779-30-9
- References: Kuipers, F., Claudel, T., Sturm, E., & Staels, B. (2004). The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism. Reviews in Endocrine and Metabolic Disorders, 5(4), 319-326. Dai, J., Wang, H., Shi, Y., Dong, Y., Zhang, Y., & Wang, J. (2011). Impact of bile acids on the growth of human cholangiocarcinoma via FXR. J Hematol Oncol, 4, 41. Liu, Y., Binz, J., Numerick, M. J., Dennis, S., Luo, G., Desai, B., ... & Jones, S. A. (2003). Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis. The Journal of clinical investigation, 112(11), 1678-1687.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid
- Molecular Weight: 542.8
- Molecular Formula: C28H22Cl3NO4
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl