Human EpCAM / TROP1 Protein, Llama IgG2b Fc Tag, low endotoxin

DESCRIPTION

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

DETAILS

Tag: C-LlamaFc(LlamaIgG2b)
Host: HEK293
Size: 1mg
Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Format: Powder
Purity: 95%
Source: Human EpCAM, Llama IgG2b Fc Tag (EPM-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Lys 265 (Accession # AAH14785.1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: EpCAM
Accession: AAH14785.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Gln 24 - Lys 265
Package Size: 1mg*1
Characteristics: This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 55.2 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 0.01 EU per μg
Molecular Weight: 55.2 kDa
Shipping Condition: RT
Species Reactivity: Human
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