Anti-NF68 Monoclonal Antibody (Clone: NR4)

DESCRIPTION

Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 kD(NFL), 125 kD(NFM) and 200 kD(NFH) on SDS-gel electrophoresis. And they have a role in the maturation of regenerating myelinated axons. Neurofilament 68(NF68), also called Neurofilament Protein, Light Chain(NFL). It is one of the most abundant cytoskeletal components of the neuron. Mutations in this gene were reported as a cause for autosomal dominant Charcot-Marie-Tooth type 2E(CMT2E) linked to chromosome 8p21. NFL was identified repeatedly in both screenings and found to interact with Myotubularin-related 2 gene, MTMR2 in both Schwann cells and neurons.

DETAILS

Gene: Nefl
App Id: WB,IHC-P,IHC-F
Antigen: Neurofilament light polypeptide
Gene Id: 83613
Isotype: Mouse IgG1
Clone Name: NR4
Uniprot Id: P19527
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Ascites
Reactivity Id: Human
Product Content: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Alternative Name: Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein; Nefl; Nf68, Nfl
Application Note: Western blot : 1-2µg/ml; Immunohistochemistry(Paraffin-embedded Section) : 2-4µg/ml; Immunohistochemistry(Frozen Section) : 2-4µg/ml
Storage Condition: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Immunogen Information: Pig spinal cord.