32-1718
sRANKL His Recombinant Protein
Abeomics
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DESCRIPTION
Source : Escherichia Coli.
sRANKL Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (140-317 a.a) & having a molecular mass of 22.3kDa.sRANKL is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RANKL binds to tnfrsf11b/opg & to tnfrsf11a/rank. Osteoclast differentiation & activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells & dendritic cells & may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
DETAILS
- Amino Acid: MGSSHHHHHH SSGLVPRGSH MIRAEKAMVD GSWLDLAKRS KLEAQPFAHL TINATDIPSG SHKVSLSSWY HDRGWAKISN MTFSNGKLIV NQDGFYYLYA NICFRHHETS GDLATEYLQL MVYVTKTSIK IPSSHTLMKG GSTKYWSGNS EFHFYSINVG GFFKLRSGEE ISIEVSNPSL LDPDQDATYF GAFKVRDID.
- Purification: Greater than 80.0% as determined by SDS-PAGE.
- Product Content: sRANKL protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl & 1mM DTT.
- Alternative Name: Soluble Receptor Activator of NFkB Lig&||TNFSF11||TRANCE||TNF-related activation-induced cytokine||OPGL||ODF||Osteoclast differentiation factor||Tumor necrosis factor lig& superfamily member 11.
- Storage Condition: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.